Cures "Tumeric Max"
The volatile oil fraction of turmeric has demonstrated significant anti-inflammatory activity in a variety of experimental models. Even more potent than its volatile oil is the yellow or orange pigment of turmeric, which is called curcumin. Curcumin is thought to be the primary pharmacological agent in turmeric. In numerous studies, curcumin's anti-inflammatory effects have been shown to be comparable to the potent drugs hydrocortisone and phenylbutazone as well as over-the-counter anti-inflammatory agents such as Motrin. Unlike the drugs, which are associated with significant toxic effects (ulcer formation, decreased white blood cell count, intestinal bleeding), curcumin produces no toxicity.
Plant Cures makes no claims, however In India (Where turmeric is
widely used) the prevalence of four common U.S. cancers -- colon, breast,
prostate and lung -- is 10 times lower. In fact, prostate cancer, which is
the most frequently diagnosed cancer in U.S. men, is very rare in
India. Many studies have taken
place to this potential cancer-fighting link. The results are quite
promising as they have found curcumin to: Inhibit the proliferation of tumor cells, inhibit the
transformation of cells from normal to tumor, help your body destroy
mutated cancer cells so they cannot spread throughout your body Decrease
inflammation, enhance liver function, Inhibit the synthesis of a protein
thought to be instrumental in tumor formation, and prevent the development
of additional blood supply necessary for cancer cell growth.
Curcumin may provide an inexpensive, well-tolerated, and effective treatment for inflammatory bowel disease (IBD) such as Crohn's and ulcerative colitis, recent research suggests. In this study, mice given an inflammatory agent that normally induces colitis were protected when curcumin was added to their diet five days beforehand. The mice receiving curcumin not only lost much less weight than the control animals, but when researchers checked their intestinal cell function, all the signs typical of colitis (mucosal ulceration, thickening of the intestinal wall, and the infiltration of inflammatory cells)were all much reduced. While the researchers are not yet sure exactly how curcumin achieves its protective effects, they think its benefits are the result of not only antioxidant activity, but also inhibition of a major cellular inflammatory agent called NF kappa-B. Plus, an important part of the good news reported in this study is the fact that although curcumin has been found to be safe at very large doses, this component of turmeric was effective at a concentration as low as 0.25 per cent-an amount easily supplied by simply enjoying turmeric in flavorful curries.
Relief for Rheumatoid Arthritis
Clinical studies have substantiated that curcumin also exerts very powerful antioxidant effects. As an antioxidant, curcumin is able to neutralize free radicals, chemicals that can travel through the body and cause great amounts of damage to healthy cells and cell membranes. This is important in many diseases, such as arthritis, where free radicals are responsible for the painful joint inflammation and eventual damage to the joints. Turmeric's combination of antioxidant and anti-inflammatory effects explains why many people with joint disease find relief when they use the spice regularly. In a recent study of patients with rheumatoid arthritis, curcumin was compared to phenylbutazone and produced comparable improvements in shortened duration of morning stiffness, lengthened walking time, and reduced joint swelling.
Help for Cystic Fibrosis Sufferers
Curcumin, the major constituent of turmeric that gives the spice its yellow color, can correct the most common expression of the genetic defect that is responsible for cystic fibrosis, suggests an animal study published in the Science (April 2004). Cystic fibrosis, a fatal disease that attacks the lungs with a thick mucus, causing life-threatening infections, afflicts about 30,000 American children and young adults, who rarely survive beyond 30 years of age. The mucus also damages the pancreas, thus interfering with the body-ability to digest and absorb nutrients.
Researchers now know that cystic fibrosis is caused by mutations in the gene that encodes for a protein (the transmembrane conductance regulator or CFTR). The CTFR protein is responsible for traveling to the cell-surface and creating channels through which chloride ions can leave the cell. When the protein is abnormally shaped because of a faulty gene, this cannot happen, so chloride builds up in the cells, which in turn, leads to mucus production.
The most common mutation, which is called DeltaF508,
results in the production of a misfolded protein. When mice with this
DeltaF508 defect were given curcumin in doses that, on a weight-per-weight
basis, would be well-tolerated by humans, curcumin corrected this defect,
resulting in a DeltaF508 protein with normal appearance and function. In
addition, the Yale scientists studying curcumin have shown that it can
inhibit the release of calcium, thus allowing mutated CTFR to exit cells
via the calcium channels, which also helps stop the chloride-driven build
up of mucus. Specialists in the treatment of cystic fibrosis caution,
however, that patients should not self-medicate with dietary supplements
containing curcumin, until the correct doses are known and any adverse
interactions identified with the numerous prescription drugs taken by
cystic fibrosis sufferers.